The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

By Dennis Dennis | Posted at 17:50

It was a good year for mice. The headline in Medical Daily last week is typical: “Reproductive scientists create mice from 2 fathers.” It seems that through impressive scientific jiggery-pokery in the lab, researchers at M.D. Anderson Cancer Center were able to extract a cell from each of two male mice, combine their DNA, put the results into a surrogate mouse mother, and produce a mouseling that was not genetically related to the mother at all. (What has this to do with cancer research? Good question.)

Thus, we may presume, was hope given to the uncounted childless mouse couples. Indeed, scientists seem to have devoted themselves to the improvement of mousekind. Just this year:

If one didn’t know better, one might suppose that there’s a vast international effort to produce Mighty Mouse, though no one has yet come up with a rodent that can sing, “here I come to save the day.”

The scientists are very clever, though. As they produce new mice that will oneday rule us all, they claim that they are doing “medical research” that will oneday benefit “humans.”
Right.

We’re all the time hearing — the above are just a few examples — of medical breakthroughs that improve and enrich mousedom. When was the last time you heard of one of these miracles making its way to treatments useful to people?

Actually, the barriers to experimental findings making their way to real-world therapies are very, perhaps absurdly, high. Some of us may remember the short story and novel, Flowers for Algernon, or the movie of it, Charly, in which surgery made a mouse smarter so, right off the bat, the doctors performed the same surgery on a human. It doesn’t work that way, but what really happens can be as ridiculous in the other direction.

Before any treatment is approved for use on humans, it must go through a series of increasingly difficult tests, from initial peer-reviewed publication through limited then clinical testing, and finally, perhaps, approval. This makes sense, but we must remember that at each step there are scientists and others who are subject to the same jealousies and prejudices as everyone else. Science can also be very political. There is, too, the fact that every step is expensive. Scientists often spend a lot of time outside the lab, looking for someone who will pay for their research. Clinical trials alone can cost millions of dollars.

Then there is the Food and Drug Administration, which subjects potential treatments to what amounts to a full political examination. I personally know of one case in which a brilliant scientist, Dr. Michael Zasloff, then of the National Institutes of Health, discovered a family of highly effective, non-toxic, antimicrobial compounds to which bacteria could not become resistant. The discovery made the front page of the Washington Post and other publications. It was an incredible discovery.

He named the compounds “magainins.” You can look them up if you want, but the story will not increase your faith in the system. Let it suffice for me to say that though many people sought approval of products using magainins (especially diabetics who need the products for the treatment of ulcers that often lead to amputation of their feet), the FDA for no apparent reason rejected those products. I have read the transcripts of their hearings and found it all appalling.

But, hey, let’s not let that throw cold water on the important new research that is underway to make mice stronger and smarter and more long-lived. From a purely academic perspective, this is very interesting stuff. And, who knows, maybe oneday it will be good for something.

In the meantime, let us hope that the new supermice don’t get loose.

Dennis E. Powell is crackpot-at-large to Open for Business. Powell was an award-winning reporter in New York and elsewhere before moving to Ohio and becoming a full-time crackpot. You can reach him at dep@drippingwithirony.com.



Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice
Posted by Aliya - Aug 15, 2017 | 8:23

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

Later, they found that a spirit was harming their daughter, Andrea. Frightened by these conditions, Rod and Carolyn called on the investigators to help them out with this mess. Showbox

Posted by Alexandr Lukin - Sep 25, 2017 | 13:23

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice
Posted by Alexandr Lukin - Sep 30, 2017 | 15:02

check cashing spring-valley

We are happy you just read this specific. This can be a form of guide book which needs to be granted but not your hit-or-miss untruths that’s with the various other websites. Currently follow-up check cashing spring-valley Take pleasure in your current expressing this specific ideal putting up.

Posted by Pervez - Oct 1, 2017 | 17:26

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

At Hotstar, we are super excited about shaping the OTT video space in India and being part of history-in-the-making as we innovate on product development, consumer lifecycle and ad-monetization. Hotstar

Posted by Alexandr Lukin - Oct 3, 2017 | 6:16

HAIWONGROUP7

Introduce me blogging indonesia want to visit on your website and read the contents of article useful for me,
if any time please visit our website 

obat kuat

cara membesarkan alat vital pria dengan tangan

Posted by mas ulul - Oct 4, 2017 | 0:49

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

Popcorn Time's interface is elegant and intuitive. On the first screen of the app you can quickly access any of the latest releases available to download, and you can access the selection of series or the search tool just by tapping on the screen. popcorn time

Posted by Alexandr Lukin - Oct 9, 2017 | 14:10

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

I found this is an informative and interesting post so i think so it is very useful and knowledgeable. I would like to thank you for the efforts you have made in writing this article.

Posted by Automotive Locksmith - Nov 2, 2017 | 13:55

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

This is such a great resource that you are providing and you give it away for free.

Posted by find more - Nov 6, 2017 | 13:06

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

Positive site, where did u come up with the information on this posting?I have read a few of the articles on your website now, and I really like your style. Thanks a million and please keep up the effective work.

Posted by get more info - Nov 6, 2017 | 13:27

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

This article gives the light in which we can observe the reality. This is very nice one and gives in depth information. Thanks for this nice article.

Posted by Mattress mama - Nov 7, 2017 | 11:32

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

I am very enjoyed for this blog. Its an informative topic. It help me very much to solve some problems. Its opportunity are so fantastic and working style so speedy.

Posted by Bryant Digital - Nov 8, 2017 | 9:59

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

Good article, but it would be better if in future you can share more about this subject. Keep posting.

Posted by Dolce Vita - Nov 11, 2017 | 7:38

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

The information you have posted is very useful. The sites you have referred was good. Thanks for sharing…

Posted by Eesti e-sport - Nov 20, 2017 | 6:24

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

Excellent article. Very interesting to read. I really love to read such a nice article. Thanks! keep rocking.

Posted by pokemon go hack pl - Nov 21, 2017 | 8:05

Re: The View from Mudsock Heights: Forget the Better Mousetrap -- We’re Building Better Mice

This article gives the light in which we can observe the reality. This is very nice one and gives in depth information. Thanks for this nice article.

Posted by phone for charity - Nov 23, 2017 | 12:14

Please enter your comment entry below. Press 'Preview' to see how it will look.

Name:
Sign In to Your Account
User Name:
Password:
Location:
Homepage:
E-mail:
Subject:
:mrgreen: :neutral: :twisted: :arrow: :shock: :smile: :???: :cool: :evil: :grin: :idea: :oops: :razz: :roll: :wink: :cry: :eek: :lol: :mad: :sad: :!: :?:
Home About Connect: Twitter Facebook RSS
© 2001-2012 Universal Networks, All Rights Reserved. Some content rights may be held by Universal Networks' providers and used under license. Powered by ServerForest and SAFARI. Learn about our privacy policy here.